Analytical Data
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基因名
FMNL1
- Application
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别名
8030453N10Rik; AI553564; C17orf1; C17orf1B; CLL associated antigen KW 13; CLL-associated antigen KW-13; FHOD4; FMNL; FMNL_HUMAN; Fmnl1; Fnrl; Formin like 1; Formin like; Formin related protein; Formin-like protein 1; Frls; KW 13
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95466
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表达区间
1-463aa
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氨基酸序列
MPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLQVTSEVSL
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分子量
78.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FMNL1 (Formin-like 1) is a member of the formin protein family, which plays a crucial role in the regulation of actin dynamics, a fundamental process for various cellular functions, including motility, division, and morphology. The study of FMNL1 has gained significance due to its implications in cellular processes such as cytokinesis, filopodia formation, and actin filament organization. Aberrations in FMNL1 expression have been linked to various pathological conditions, including cancer, where enhanced activity may contribute to increased cell migration and invasion. Researchers have focused on the structural and functional characterization of FMNL1, particularly its interactions with other cellular components and regulatory proteins, underscoring its role in the actin cytoskeleton. By employing recombinant protein techniques, scientists aim to obtain purified FMNL1 to elucidate its mechanistic functions and potential as a therapeutic target. The understanding of FMNL1’s activity and regulation holds promise for developing novel interventions in diseases characterized by altered cell motility and actin dysregulation. Overall, FMNL1 remains a pivotal focus in cell biology and disease research, making its study essential for uncovering broader insights into cellular dynamics and their implications in health and disease.
