Analytical Data
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Gene name
FMNL1
- Application
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Alternative Names
8030453N10Rik; AI553564; C17orf1; C17orf1B; CLL associated antigen KW 13; CLL-associated antigen KW-13; FHOD4; FMNL; FMNL_HUMAN; Fmnl1; Fnrl; Formin like 1; Formin like; Formin related protein; Formin-like protein 1; Frls; KW 13
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95466
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Expression Region
1-463aa
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AA Sequence
MPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLQVTSEVSL
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Molecular Weight
78.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FMNL1 (Formin-like 1) is a member of the formin protein family, which plays a crucial role in the regulation of actin dynamics, a fundamental process for various cellular functions, including motility, division, and morphology. The study of FMNL1 has gained significance due to its implications in cellular processes such as cytokinesis, filopodia formation, and actin filament organization. Aberrations in FMNL1 expression have been linked to various pathological conditions, including cancer, where enhanced activity may contribute to increased cell migration and invasion. Researchers have focused on the structural and functional characterization of FMNL1, particularly its interactions with other cellular components and regulatory proteins, underscoring its role in the actin cytoskeleton. By employing recombinant protein techniques, scientists aim to obtain purified FMNL1 to elucidate its mechanistic functions and potential as a therapeutic target. The understanding of FMNL1’s activity and regulation holds promise for developing novel interventions in diseases characterized by altered cell motility and actin dysregulation. Overall, FMNL1 remains a pivotal focus in cell biology and disease research, making its study essential for uncovering broader insights into cellular dynamics and their implications in health and disease.
