Analytical Data
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基因名
EIF6
- Application
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别名
EIF6;EIF3A;ITGB4BP;Eukaryotic translation initiation factor 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56537
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表达区间
1-245aa
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氨基酸序列
MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EIF6 (Eukaryotic Translation Initiation Factor 6) is a pivotal protein involved in the regulation of protein synthesis and ribosome biogenesis. It plays a crucial role in the initiation of translation by facilitating the assembly of the ribosomal subunits and ensuring the proper recruitment of the initiator methionyl-tRNA to the ribosome. Recent studies have highlighted its significance not only in normal cellular processes but also in various pathological conditions, including cancer. Aberrant expression of EIF6 has been linked to the enhancement of oncogenic signaling pathways, promoting cell proliferation and survival. This has made EIF6 an attractive target for therapeutic interventions. Research has increasingly focused on recombinantly producing EIF6 to investigate its structural and functional characteristics, as well as its interactions with other cellular factors. Understanding the mechanisms underlying EIF6 function may provide insights into its role in disease progression and open new avenues for the development of targeted treatments. The study of EIF6 as a recombinant protein has also paved the way for the exploration of its potential as a biomarker and its utility in the design of novel therapeutic strategies aimed at modulating translational control in diseases associated with dysregulated protein synthesis. Overall, the research on EIF6 and its recombinant forms is crucial for unraveling the complexities of translational regulation and its implications in health and disease.












