Analytical Data
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Gene name
EIF2D
- Application
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Alternative Names
EIF2D；HCA56；LGTN；Eukaryotic translation initiation factor 2D
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41214
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Expression Region
1-584aa
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AA Sequence
MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE APEDTSTRGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIVINYAK KNDLVDADNK NLVRLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE PIVKKGRICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EIF2D, a member of the eukaryotic translation initiation factor family, has gained increasing attention in molecular biology and cancer research due to its significant role in the process of protein synthesis and cellular stress responses. Specifically, EIF2D is involved in the initiation phase of translation, essential for cellular growth, survival, and regulation of gene expression. Recent studies have shown that dysfunctions or mutations in EIF2D can lead to various diseases, including certain types of cancer and neurodegenerative disorders. Therefore, the recombinant production of EIF2D protein is crucial for understanding its biological functions and the mechanisms underlying diseases. By studying this protein in detail, researchers aim to elucidate its role in translational control and cellular stress responses, which could open new avenues for therapeutic interventions. The development of recombinant EIF2D will enable researchers to perform biochemical assays, structural analyses, and functional studies that are essential for elucidating its mechanism of action and potential as a therapeutic target. Moreover, understanding how EIF2D interacts with other molecular players in translation initiation can provide insights into the regulatory networks that maintain cellular homeostasis and how their dysregulation contributes to disease states. Overall, the study of recombinant EIF2D is a promising area of research that holds potential implications for cancer biology and the development of novel treatment strategies.
