Analytical Data
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基因名
HIST1H2AG
- Application
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别名
HIST1H2AG；H2AFP；HIST1H2AG；H2AC13；Histone H2A type 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0C0S8
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表达区间
2-130aa
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氨基酸序列
SGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
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分子量
18.0kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AG is a gene that encodes a histone protein, specifically a member of the H2A histone family, which plays a crucial role in the packaging and regulation of DNA within the cell nucleus. Its involvement in chromatin structure suggests a significant role in gene expression regulation, DNA repair, and cellular aging. Research has indicated that alterations or mutations in histone proteins can lead to various diseases, including cancers, by influencing chromatin dynamics and accessibility of genomic regions. Moreover, histone modifications and variants, such as those produced by HIST1H2AG, are important for epigenetic regulation, affecting how genes are turned on or off without changing the underlying DNA sequence. Recent studies have aimed to elucidate the functional implications of HIST1H2AG in different biological contexts, including its potential role in tumorigenesis and therapeutic responses. As such, recombinant HIST1H2AG proteins are being utilized in experimental settings to further understand their biochemical properties, interactions with DNA, and overall contribution to cellular processes. This research not only helps in uncovering the fundamental mechanisms of gene regulation but also paves the way for potential therapeutic strategies targeting histone modifications in disease contexts.
