Analytical Data
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基因名
HIST1H2AB
- Application
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别名
HIST1H2AB；H2AFM；HIST1H2AB；H2AC8；Histone H2A type 1-B/E
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04908
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表达区间
2-130aa
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氨基酸序列
SGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AB is a gene that encodes a histone protein, specifically a member of the histone H2A family, playing a crucial role in the structural organization of chromatin and the regulation of gene expression. Histones are responsible for packaging DNA into a compact, organized structure and are involved in various cellular processes including DNA replication, repair, and transcription regulation. Research on HIST1H2AB is particularly relevant in understanding its role in cancer biology, as alterations in histone modifications and expression patterns are frequently observed in various malignancies. Additionally, the significance of histone proteins extends to epigenetic mechanisms, where changes in histone modifications can lead to lasting changes in gene expression without altering the underlying DNA sequence. Investigating the functions and regulations of HIST1H2AB, as well as its potential interactions with other cellular factors, is essential for elucidating its contribution to cellular homeostasis and pathology, thus providing potential avenues for therapeutic interventions in diseases characterized by epigenetic dysregulation. The ongoing study of HIST1H2AB and its recombinant protein variants might reveal critical insights into how histone modifications affect cellular processes, contributing to advancements in molecular biology and medicine.
