Analytical Data
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Gene name
HIST1H2AB
- Application
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Alternative Names
HIST1H2AB；H2AFM；HIST1H2AB；H2AC8；Histone H2A type 1-B/E
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04908
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Expression Region
2-130aa
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AA Sequence
SGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AB is a gene that encodes a histone protein, specifically a member of the histone H2A family, playing a crucial role in the structural organization of chromatin and the regulation of gene expression. Histones are responsible for packaging DNA into a compact, organized structure and are involved in various cellular processes including DNA replication, repair, and transcription regulation. Research on HIST1H2AB is particularly relevant in understanding its role in cancer biology, as alterations in histone modifications and expression patterns are frequently observed in various malignancies. Additionally, the significance of histone proteins extends to epigenetic mechanisms, where changes in histone modifications can lead to lasting changes in gene expression without altering the underlying DNA sequence. Investigating the functions and regulations of HIST1H2AB, as well as its potential interactions with other cellular factors, is essential for elucidating its contribution to cellular homeostasis and pathology, thus providing potential avenues for therapeutic interventions in diseases characterized by epigenetic dysregulation. The ongoing study of HIST1H2AB and its recombinant protein variants might reveal critical insights into how histone modifications affect cellular processes, contributing to advancements in molecular biology and medicine.
