Analytical Data
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Gene name
HIST1H2AA
- Application
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Alternative Names
HIST1H2AA；H2AFR；HIST1H2AA；Histone H2A type 1-A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96QV6
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Expression Region
2-131aa
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AA Sequence
SGRGKQGGK ARAKSKSRSS RAGLQFPVGR IHRLLRKGNY AERIGAGAPV YLAAVLEYLT AEILELAGNA SRDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK TESHHHKAQS K
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AA is a gene that encodes a core histone protein, which plays a critical role in the formation of nucleosomes—the fundamental units of chromatin structure in eukaryotic cells. The importance of HIST1H2AA in regulating gene expression and maintaining genomic stability has sparked interest in its characterization and potential applications in biomedical research. Histones are subject to a variety of post-translational modifications, which can influence DNA accessibility and, consequently, gene activity. Dysregulation of histone modifications is implicated in various diseases, including cancers and genetic disorders. Research into HIST1H2AA has mainly focused on understanding its expression patterns, interaction with other nuclear proteins, and role in epigenetic regulation. Recombinant HIST1H2AA protein production allows for detailed studies of its biochemical properties, enabling researchers to explore how it interacts with DNA and other chromatin-associated factors. This understanding is pivotal for elucidating the mechanisms of chromatin remodeling and provides insights into therapeutic strategies for diseases linked to epigenetic alterations. Consequently, the investigation of HIST1H2AA and its recombinant protein contributes to the broader knowledge of histone biology and its implications in health and disease.
