Analytical Data
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基因名
USP13
- Application
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别名
Deubiquitinating enzyme 13; Isopeptidase T 3; Isopeptidase T-3; Isopeptidase T3; ISOT 3; ISOT-3; ISOT3; Ubiquitin carboxyl terminal hydrolase 13; Ubiquitin carboxyl-terminal hydrolase 13; Ubiquitin specific peptidase 13 (isopeptidase T3); Ubiquitin specific peptidase 13; Ubiquitin specific processing protease 13; Ubiquitin specific protease 13; Ubiquitin thioesterase 13; Ubiquitin thiolesterase 13; Ubiquitin-specific-processing protease 13; UBP13; UBP13_HUMAN; USP 13; USP13
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92995
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表达区间
1-863 aa
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氨基酸序列
MQRRGALFGMPGGSGGRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNSKIFLDLDTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPDTWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHLAKHLAHFGIDMLHMHGPENGLQDNDIKLRVSEWEVIQESGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYAERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKIPFSACLQAFSEPENVDGFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSIDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDCLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWIIVHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEMENNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRIPS
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分子量
121.44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USP13, short for Ubiquitin-specific protease 13, is a member of the deubiquitinating enzyme family, which plays a crucial role in the removal of ubiquitin moieties from target proteins, thereby regulating various cellular processes, including protein degradation, cell cycle progression, and signal transduction. Recent studies have highlighted the significance of USP13 in various physiological and pathological contexts, such as its involvement in cancer progression, neurodegeneration, and immune response modulation. Its activity can influence the stability and functional status of numerous substrates, making it a potential therapeutic target for drug discovery. The recombinant production of USP13 is essential for understanding its enzymatic mechanisms and substrate interactions. By expressing USP13 in suitable host systems, researchers can obtain purified protein for biophysical and biochemical assays, enabling them to elucidate its structure-function relationship. Additionally, studying USP13's role in disease mechanisms can pave the way for the development of small molecule inhibitors or activators, potentially providing novel avenues for therapeutic interventions. Overall, the investigation of USP13 and its functional implications is critical for advancing our understanding of ubiquitin-mediated regulation in health and disease.
