Analytical Data
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基因名
USP11
- Application
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别名
Deubiquitinating enzyme 11; Ubiquitin carboxyl-terminal hydrolase 11; Ubiquitin carboxyl-terminal hydrolase X linked; ubiquitin specific peptidase 11; Ubiquitin specific protease 11; Ubiquitin thiolesterase 11; Ubiquitin-specific-processing protease 11; UBP11_HUMAN; UHX1; USP11
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51784
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表达区间
201-300 aa
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氨基酸序列
LVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDE
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分子量
36.74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USP11 (Ubiquitin-specific protease 11) is a member of the deubiquitinating enzyme family, which plays a crucial role in the regulation of protein degradation and signaling pathways through the removal of ubiquitin moieties from target proteins. Understanding the functional implications of USP11 is particularly important given its involvement in various cellular processes, including cell cycle regulation, DNA repair, and responses to stress. Recent studies have highlighted its potential role in cancer biology, suggesting that USP11 may contribute to tumorigenesis by regulating the stability of oncogenic proteins and influencing apoptosis. The interest in USP11 extends to its potential as a therapeutic target, prompting research into its molecular mechanisms and interactions with substrates. The production and study of recombinant USP11 protein are essential for elucidating its biochemical properties, substrate specificity, and functional roles within the cell. By generating purified USP11 through recombinant DNA technology, researchers can conduct in vitro assays to explore its enzymatic activity and investigate how it modulates various cellular pathways. This research not only enhances our understanding of USP11's biological significance but also opens avenues for developing novel therapeutic strategies aimed at targeting the dysregulation of ubiquitin-proteasome systems in diseases such as cancer.
