Analytical Data
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基因名
UHMK1
- Application
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别名
DKFZp434C1613; FLJ23015; kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; KIS; KIS Protein kinase; KIST; OTTHUMP00000029529; P-CIP2; Serine threonine Protein kinase Kist; Serine/threonine-Protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; UHMK1; UHMK1_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAS1
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表达区间
1-419 aa
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氨基酸序列
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV ATFYPLSAYK RGYLYQTLL
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分子量
46.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UHMK1 (U2AF Homology Motif Kinase 1) is a serine/threonine kinase predominantly involved in the regulation of pre-mRNA splicing and has been implicated in various cellular processes, including RNA metabolism, gene expression, and signal transduction. Its role in tumorigenesis and cell proliferation has garnered significant interest in the scientific community, as dysregulation of splicing factors and signaling pathways often contributes to cancer progression. Research on recombinant UHMK1 protein is crucial for elucidating its specific functions and mechanisms of action within these pathways. By producing UHMK1 as a recombinant protein, researchers can conduct detailed biochemical and biophysical analyses, facilitating the exploration of its interaction with substrate proteins and its regulatory mechanisms. Furthermore, understanding UHMK1's structural properties will aid in the development of potential therapeutic strategies targeting this kinase in cancer and other diseases linked to splicing abnormalities. Overall, the study of UHMK1 recombinant protein holds promise for advancing our knowledge of RNA processing and its implications in health and disease.
