Analytical Data
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基因名
UGT3A1
- Application
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别名
FLJ34658; UD3A1_HUMAN; UDP glycosyltransferase 3 family; polypeptide A1; UDP-glucuronosyltransferase 3A1; UDPGT 3A1; UGT3A 1; Ugt3a1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6NUS8
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表达区间
1-523 aa
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氨基酸序列
MVGQRVLLLVAFLLSGVLLSEAAKILTISTLGGSHYLLLDRVSQILQEHGHNVTMLHQSGKFLIPDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIETALDGRKESEALVKLMEIFGTQCSYLLSRKDIMDSLKNENYDLVFVEAFDFCSFLIAEKLVKPFVAILPTTFGSLDFGLPSPLSYVPVFPSLLTDHMDFWGRVKNFLMFFSFSRSQWDMQSTFDNTIKEHFPEGSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGLMEKPIKPVPQDLDNFIANFGDAGFVLVAFGSMLNTHQSQEVLKKMHNAFAHLPQGVIWTCQSSHWPRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDHILQTGGATHLKPYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLGVVARWLRGARKVKKT
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分子量
85.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UGT3A1 (UDP-glucuronosyltransferase 3A1) is a crucial enzyme involved in the metabolism and detoxification of a wide range of endogenous and exogenous compounds, including drugs, hormones, and environmental toxins. Its primary function is to catalyze the conjugation of glucuronic acid to various substrates, facilitating their excretion and reducing their biological activity. Variations in the UGT3A1 gene can lead to differences in enzyme activity among individuals, influencing the pharmacokinetics and efficacy of certain medications. Research into UGT3A1 has gained traction due to its role in drug metabolism, posing implications for personalized medicine. The recombinant expression of UGT3A1 allows scientists to produce large quantities of the enzyme for functional studies, enabling the investigation of its substrate specificity and the impact of genetic polymorphisms. Understanding the structural and functional aspects of UGT3A1 through recombinant protein studies can provide insights into its regulatory mechanisms and potential interactions with various therapeutic agents, which is vital for developing effective treatment strategies and minimizing adverse drug reactions. Given the increasing complexity of drug formulations and the growing focus on individualized healthcare, the exploration of UGT3A1 remains a significant area of study in pharmacology and toxicology.
