Analytical Data
-
Gene name
CUBN
- Application
-
Alternative Names
CUBN；IFCR；Cubilin
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O60494
-
Expression Region
全长
-
AA Sequence
full
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CUBN, also known as cubilin, is a multiligand receptor primarily expressed in the renal proximal tubules, playing a crucial role in the reabsorption of protein and other macromolecules from the nephron. Its ability to bind a variety of ligands, including the intrinsic factor-vitamin B12 complex and various proteases, underscores its importance in both nutrient absorption and the maintenance of physiological homeostasis. Research on CUBN has gained momentum due to its implications in various pathological conditions, including renal diseases and vitamin B12 deficiency. Mutations in the CUBN gene have been linked to disorders such as Imerslund-Grasbeck syndrome, characterized by malabsorption of vitamin B12 and subsequent anemia. In addition to its role in renal function, CUBN's involvement in other tissues and potential roles in cellular signaling pathways make it a subject of interest in cancer research and developmental biology. As such, the study of recombinant CUBN proteins offers insights into its structural and functional properties, facilitating the development of therapeutic strategies aimed at modulating its activity in disease states. The ongoing research efforts aim to elucidate the mechanistic pathways governed by CUBN and to explore its potential as a biomarker for various diseases, highlighting the need for comprehensive studies to fully understand its physiological and pathological roles.
