Analytical Data
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Gene name
FLJ22374
- Application
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Alternative Names
C7orf67; Chromosome 7 open reading frame 67; F188B_HUMAN; Fam188b; Family with sequence similarity 188; member B; FLJ22374; FLJ51453; Hypothetical protein LOC84182; MGC44277; OTTHUMP00000202456; Protein FAM188B
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q4G0A6
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Expression Region
1-757aa
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AA Sequence
MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV LHLEFLYKEN KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV PKKNNKVPSR CSETTLVNIY DLSDEDAGWR TSLSETSKAR HDNLDGDVLG NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE KIDKLHSEPS LDVKRMGENS RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ PQEESRKVPE LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ GSQPAPVRKN QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL QTASKPIDLS VAKEIKTLLF GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ NKGGPCGVLA AVQGCVLQKL LFEGDSKADC AQGLQPSDAH RTRCLVLALA DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL HSLTCYEDLV TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF EHYNMCQVGC FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL YYYDGLANQQ EQIRLTIDTT QTISEDTDND LVPPLELCIR TKWKGASVNW NGSDPIL
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Molecular Weight
84.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FLJ22374, also known as C9orf72, is a gene associated with several neurodegenerative diseases, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The significance of FLJ22374 lies in its role in the accumulation of dipeptide repeat proteins (DPRs) resulting from hexanucleotide repeat expansions in the non-coding region of the gene. Research has focused on understanding the molecular mechanisms behind these repeat expansions and their contribution to cellular toxicity, neuroinflammation, and neuronal death. Studies have shown that the abnormal accumulation of DPRs disrupts cellular functions, leading to impaired protein homeostasis, mitochondrial dysfunction, and altered RNA metabolism. Furthermore, FLJ22374 is of interest not only for its genetic implications but also for its potential as a therapeutic target. Protein-based therapies aiming to mitigate the toxic effects of DPRs or restore normal gene function are being explored. Understanding the structure and function of FLJ22374 recombinant proteins can provide valuable insights into disease mechanisms and aid in the development of novel therapeutic strategies. As research continues to evolve, the study of FLJ22374 and its recombinant proteins holds promise for unveiling new pathways for intervention in FTD and ALS, ultimately contributing to better treatment options for affected patients.
