Analytical Data
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Gene name
UBE2CBP
- Application
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Alternative Names
C6orf157; chromosome 6 open reading frame 157; DKFZp434A1520; EC 6.3.2; EC 6.3.2.-; H10BH; MGC126561; MGC126587; OTTHUMP00000016789; OTTHUMP00000220801; UB2CB_HUMAN; UBCH10 binding Protein with a hect-like domain; UbcH10-binding Protein with a HECT-like domain; UBE2CBP; Ubiquitin-conjugating enzyme E2C-binding Protein; YJR141W
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z6J8
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Expression Region
2-389 aa
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AA Sequence
AASAAETRV FLEVRGQLQS ALLILGEPKE GGMPMNISIM PSSLQMKTPE GCTEIQLPAE VRLVPSSCRG LQFVVGDGLH LRLQTQAKLG TKLISMFNQS SQTQECCTFY CQSCGEVIIK DRKLLRVLPL PSENWGALVG EWCCHPDPFA NKSLHPQEND CFIGDSFFLV NLRTSLWQQR PELSPVEMCC VSSDNHCKLE PKANTKVICK RCKVMLGETV SSETTKFYMT EIIIQSSERS FPIIPRSWFV QSVIAQCLVQ LSSARSTFRF TIQGQDDKVY ILLWLLNSDS LVIESLRNSK YIKKFPLLEN TFKADSSSAW SAVKVLYQPC IKSRNEKLVS LWESDISVHP LTLPSATCLE LLLILSKSNA NLPSSLRRVN SFQVAFLKM
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Molecular Weight
43.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBE2CBP, a member of the ubiquitin-conjugating enzyme family, plays a crucial role in the ubiquitin-proteasome system, which regulates protein degradation and turnover within cells. This enzyme is particularly implicated in modulating the stability and function of various target proteins by facilitating the attachment of ubiquitin molecules, thereby marking them for degradation. Research has highlighted UBE2CBP's involvement in critical biological processes, including cell cycle regulation, DNA repair, and various signaling pathways. Aberrations in UBE2CBP activity have been linked to several diseases, especially cancer, where altered protein degradation can lead to the accumulation of oncogenic proteins or the loss of tumor suppressors. The investigation of UBE2CBP not only enhances our understanding of the fundamental mechanisms of protein homeostasis but also opens avenues for therapeutic interventions that target the ubiquitin-proteasome system. Studies have focused on elucidating its structural characteristics, substrate specificity, and the regulatory networks it participates in, with the aim of developing strategies to manipulate its function for potential clinical benefits. Thus, UBE2CBP represents a significant focus in the fields of molecular biology and cancer research, as harnessing its activity could lead to innovative treatments for diseases characterized by dysregulated protein turnover.
