Analytical Data
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基因名
UBE1DC1
- Application
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别名
5730525G14Rik; AW240750; FLJ23251; FLJ23251UBA5; MGC105565; ThiFP1; UBA5; UBA5 ubiquitin activating enzyme E1 homolog; UBA5_HUMAN; UBE1DC; UBE1DC1; Ubiquitin activating enzyme 5; Ubiquitin activating enzyme E1 domain containing 1; Ubiquitin activating enzyme E1 domain containing Protein 1; Ubiquitin like modifier activating enzyme 5; Ubiquitin-activating enzyme 5; Ubiquitin-activating enzyme E1 domain-containing Protein 1; Ubiquitin-like modifier-activating enzyme 5; UFM1 activating enzyme; UFM1-activating enzyme
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9GZZ9
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表达区间
1-404 aa
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氨基酸序列
MAESVERLQQ RVQELERELA QERSLQVPRS GDGGGGRVRI EKMSSEVVDS NPYSRLMALK RMGIVSDYEK IRTFAVAIVG VGGVGSVTAE MLTRCGIGKL LLFDYDKVEL ANMNRLFFQP HQAGLSKVQA AEHTLRNINP DVLFEVHNYN ITTVENFQHF MDRISNGGLE EGKPVDLVLS CVDNFEARMT INTACNELGQ TWMESGVSEN AVSGHIQLII PGESACFACA PPLVVAANID EKTLKREGVC AASLPTTMGV VAGILVQNVL KFLLNFGTVS FYLGYNAMQD FFPTMSMKPN PQCDDRNCRK QQEEYKKKVA ALPKQEVIQE EEEIIHEDNE WGIELVSEVS EEELKNFSGP VPDLPEGITV AYTIPKKQED SVTELTVEDS GESLEDLMAK MKNM
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分子量
44.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBE1DC1, a member of the ubiquitin-conjugating enzyme (E1) family, has garnered scientific interest due to its unique role in the ubiquitin-proteasome system, which is crucial for protein degradation and cellular regulation. The protein is characterized by its ability to catalyze the conjugation of ubiquitin to target proteins, thus marking them for degradation and influencing various cellular processes such as cell cycle progression, signal transduction, and stress responses. Recent studies have revealed that UBE1DC1 may play a significant role in regulating protein homeostasis and may be implicated in several diseases, including cancer and neurodegenerative disorders. Furthermore, its involvement in modulating immune responses has opened new avenues for research in immunology. Given its essential function and potential applicability in therapeutic strategies, understanding the molecular mechanisms and pathways linked to UBE1DC1 is vital. This knowledge could lead to the development of novel interventions aimed at manipulating the ubiquitin-proteasome system for disease treatment or prevention. Hence, the exploration of UBE1DC1 as a recombinant protein has become a focal point for researchers aiming to elucidate its functional roles and therapeutic potential.
