Analytical Data
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基因名
TUSC4
- Application
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别名
2810446G01Rik; G21 Protein; Gene 21 Protein; Homologous to yeast nitrogen permease (candidate tumor suppressor); Homologous to yeast nitrogen permease; Nitrogen permease regulator 2-like Protein; Nitrogen permease regulator-like 2 (S. cerevisiae); NPR 2L; NPR L2; NPR like 2; NPR2; NPR2 like; NPR2-like Protein; NPR2L; NPRL 2; NPRL2; NPRL2_HUMAN; Tumor suppressor candidate 4; TUSC 4; TUSC 4 Protein; TUSC4; TUSC4 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WTW4
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表达区间
1-380 aa
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氨基酸序列
MGSGCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL QNKLITVTAM EKKLIGCPVC IEHKKYSRNA LLFNLGFVCD AQAKTCALEP IVKKLAGYLT TLELESSFVS MEESKQKLVP IMTILLEELN ASGRCTLPID ESNTIHLKVI EQRPDPPVAQ EYDVPVFTKD KEDFFNSQWD LTTQQILPYI DGFRHIQKIS AEADVELNLV RIAIQNLLYY GVVTLVSILQ YSNVYCPTPK VQDLVDDKSL QEACLSYVTK QGHKRASLRD VFQLYCSLSP GTTVRDLIGR HPQQLQHVDE RKLIQFGLMK NLIRRLQKYP VRVTREEQSH PARLYTGCHS YDEICCKTGM SYHELDERLE NDPNIIICWK
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分子量
43.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUSC4, also known as Tumor Suppressor Candidate 4, is a gene located on chromosome 3 and has been implicated in various cancer types due to its role as a tumor suppressor. Research shows that TUSC4 expression is frequently downregulated in several malignancies, suggesting its potential role in tumorigenesis. The loss of TUSC4 expression has been linked to increased cellular proliferation and reduced apoptosis, highlighting its importance in maintaining cellular homeostasis and genomic integrity. Studies indicate that TUSC4 may interact with key signaling pathways involved in cell cycle regulation and apoptosis, making it a candidate for understanding the molecular mechanisms of cancer development. The recombinant production of TUSC4 protein allows researchers to investigate its functional properties and interactions within cellular pathways in greater detail. This research aims to elucidate the role of TUSC4 in cancer biology, potentially leading to novel therapeutic strategies that could reinstate its function or mimic its action in cancer cells, ultimately improving patient outcomes in cancer treatment. By generating a thorough understanding of TUSC4’s mechanisms, scientists hope to contribute to the development of targeted therapies that could enhance the efficacy of existing treatments or provide new avenues for intervention in malignancies where TUSC4 is downregulated.
