Analytical Data
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基因名
FBXW2
- Application
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别名
F box and WD 40 domain containing protein 2; F box and WD repeat domain containing 2; F box and WD40 domain protein 2; F box/WD repeat containing protein 2; F-box and WD-40 domain-containing protein 2; F-box/WD repeat-containing protein 2; FBW 2; FBW2; FBXW 2; Fbxw2; FBXW2_HUMAN; Fwd2; Md6; Protein MD6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKT8
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表达区间
1-454aa
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氨基酸序列
MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG
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分子量
75.68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXW2, a member of the F-box protein family, plays a crucial role in the ubiquitin-proteasome system, which regulates protein degradation and various cellular processes. It is known to function as a substrate recognition component of SCF (SKP1-Cullin-F-box) E3 ubiquitin ligases, mediating the ubiquitination and subsequent degradation of target proteins. Research has indicated that FBXW2 is involved in the regulation of pivotal cellular functions such as cell cycle progression, signal transduction, and responses to stress. Dysregulation of FBXW2 has been implicated in various cancers and other diseases, suggesting its potential as a therapeutic target. Understanding the molecular mechanisms by which FBXW2 exerts its effects can provide insights into its role in both normal physiology and disease pathology. Recent studies have focused on elucidating the specific substrates of FBXW2 and the biological consequences of their degradation, highlighting its importance in maintaining cellular homeostasis. Furthermore, insights into FBXW2's interactions with other proteins and signaling pathways may pave the way for novel interventions in diseases linked to its dysfunction. Thus, the ongoing investigation of FBXW2 not only enhances our comprehension of cellular regulatory networks but also opens avenues for developing targeted therapies.
