Analytical Data
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Gene name
NXN
- Application
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Alternative Names
NXN；NRX；Nucleoredoxin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6DKJ4
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Expression Region
2-435aa
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AA Sequence
SGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS ASLAAFYGRL RGDAAAGPGP GAGAGAAAEP EPRRRLEIVF VSSDQDQRQW QDFVRDMPWL ALPYKEKHRK LKLWNKYRIS NIPSLIFLDA TTGKVVCRNG LLVIRDDPEG LEFPWGPKPF REVIAGPLLR NNGQSLESSS LEGSHVGVYF SAHWCPPCRS LTRVLVESYR KIKEAGQNFE IIFVSADRSE ESFKQYFSEM PWLAVPYTDE ARRSRLNRLY GIQGIPTLIM LDPQGEVITR QGRVEVLNDE DCREFPWHPK PVLELSDSNA AQLNEGPCLV LFVDSEDDGE SEAAKQLIQP IAEKIIAKYK AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM SARAKYVMDV EEITPAIVEA FVNDFLAEKL KPEPI
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NXN (Netrin-1) is a crucial protein involved in various biological processes, including neural guidance, cell migration, and angiogenesis. Understanding its structure and function has significant implications for developmental biology and therapeutic applications, especially in neurodegenerative diseases and cancer. Recent research has highlighted the role of NXN in promoting neuronal survival and regeneration, as well as its involvement in tumor progression and metastasis. The study of NXN recombinant proteins allows researchers to elucidate its molecular mechanisms and interactions with other cellular components. By expressing and purifying NXN in a recombinant form, scientists can investigate its signaling pathways, binding affinities, and potential as a therapeutic target. Moreover, understanding the dynamics of NXN can lead to innovative strategies in disease treatment, making it a focal point of current biomedical research. The advancement in recombinant DNA technology and protein expression systems has facilitated the exploration of NXN's functional properties, providing new insights into its role in health and disease. Overall, research on NXN recombinant proteins is not only pivotal for a deeper understanding of its biological functions but also holds promise for developing novel interventions against diseases where NXN plays a significant role.
