Analytical Data
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Gene name
TTLL7
- Application
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Alternative Names
RP5-836J3.2; Testis development Protein NYD-SP30; Ttll7; TTLL7_HUMAN; Tubulin polyglutamylase TTLL7; Tubulin tyrosine ligase like family member 7; Tubulin--tyrosine ligase-like Protein 7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZT98
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Expression Region
1-543 aa
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AA Sequence
MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKRANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKGRITHYVVKLFKNT
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Molecular Weight
90 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TTLL7, a member of the tubulin tyrosine ligase-like (TTLL) family, has garnered attention in recent years due to its role in post-translational modifications of tubulin, particularly in the addition of tyrosine residues to alpha-tubulin. This modification is critical for regulating microtubule dynamics and stability, influencing various cellular processes, including cell division, intracellular transport, and signaling pathways. Abnormalities in tubulin modifications are linked to several diseases, including cancer and neurodegenerative disorders, making TTLL7 a potential biomarker or therapeutic target. Researchers are investigating the structural and functional properties of TTLL7 to better understand its enzymatic mechanisms and interactions with other proteins. The production of recombinant TTLL7 protein is essential for these studies, allowing for detailed biochemical assays and structural analyses. By elucidating the function of TTLL7, scientists aim to uncover novel aspects of tubulin biology that could pave the way for innovative therapeutic strategies against diseases tied to microtubule dysfunction.
