Analytical Data
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Gene name
FBXO17
- Application
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Alternative Names
FBXO17; FBG4; FBX17; FBX26; FBXO26; F-box only protein 17; F-box only protein 26
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96EF6
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Expression Region
1-287aa
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AA Sequence
MKQGLWLLEMGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRPVCRAWRDIVDGPTVWLLQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLRAPFGRNLIFNSCGEQGFRGWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQLVDLVMEGVWQELLDSAQIEICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASPDPVLQWTERGCRQVSHVFTNFGKGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIRLS
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Molecular Weight
59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXO17, a member of the F-box protein family, has garnered attention due to its crucial role in the ubiquitin-proteasome system, which regulates protein degradation and turnover in cells. It functions as an adaptor molecule that connects substrates to the SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complex, thereby facilitating the ubiquitination of target proteins. Recent studies have highlighted FBXO17's involvement in various biological processes, including cell cycle regulation, signal transduction, and cellular stress responses. Dysregulation of FBXO17 has been implicated in several diseases, notably cancer, where it can either act as a tumor suppressor or contribute to tumor progression depending on the context. Understanding the mechanistic pathways regulated by FBXO17 could provide insights into its dual role in cell physiology and pathology. Researchers are thus focusing on characterizing FBXO17 recombinant protein to uncover its structure-function relationships, interaction partners, and regulation under different cellular conditions, which may reveal novel therapeutic targets for intervention in FBXO17-related diseases.
