Analytical Data
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Gene name
FBXL17
- Application
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Alternative Names
DKFZP434C1715; F box and leucine rich repeat protein 17 ; F box only protein 13 ; F box/LRR repeat protein 17 ; F-box and leucine-rich repeat protein 17; F-box only protein 13; F-box/LRR-repeat protein 17; FBL17; FBX13; Fbxl17; FBXO13; FXL17_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UF56
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Expression Region
1-369aa
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AA Sequence
MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCMLCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFRGPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDINQLPPSILLKVGLGERRRDARFPPPPAPASEAFSLLPLSAEEGGSLAA
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Molecular Weight
64 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXL17 is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system, a key mechanism for regulating protein degradation and maintaining cellular homeostasis. The F-box proteins function as substrate recognition components of E3 ubiquitin ligases, facilitating the transfer of ubiquitin to target proteins and marking them for degradation. FBXL17, in particular, has garnered attention due to its involvement in various biological processes, including cell cycle regulation, apoptosis, and response to stress. Recent studies have suggested that FBXL17 may be implicated in tumorigenesis and other pathological conditions, raising interest in understanding its specific functions and mechanisms. Researchers have focused on the recombinant production of FBXL17 to study its structure, function, and interactions with other cellular components in vitro. Understanding the role of FBXL17 in signaling pathways and its potential as a therapeutic target could open new avenues for cancer treatment and other diseases associated with dysregulated protein homeostasis. Furthermore, the study of FBXL17 may provide insights into the broader understanding of the ubiquitin-proteasome system and its implications in cellular health and disease.
