Analytical Data
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基因名
TTC4
- Application
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别名
TTC4; My044; Tetratricopeptide repeat Protein 4; TPR repeat Protein 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95801
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表达区间
1-387 aa
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氨基酸序列
MEQPGQDPTS DDVMDSFLEK FQSQPYRGGF HEDQWEKEFE KVPLFMSRAP SEIDPRENPD LACLQSIIFD EERSPEEQAK TYKDEGNDYF KEKDYKKAVI SYTEGLKKKC ADPDLNAVLY TNRAAAQYYL GNFRSALNDV TAARKLKPCH LKAIIRGALC HLELKHFAEA VNWCDEGLQI DAKEKKLLEM RAKADKLKRI EQRDVRKANL KEKKERNQNE ALLQAIKARN IRLSEAACED EDSASEGLGE LFLDGLSTEN PHGARLSLDG QGRLSWPVLF LYPEYAQSDF ISAFHEDSRF IDHLMVMFGE TPSWDLEQKY CPDNLEVYFE DEDRAELYRV PAKSTLLQVL QHQRYFVKAL TPAFLVCVGS SPFCKNFLRG RKVYQIR
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分子量
44.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TTC4 protein, part of the tetratricopeptide repeat (TPR) protein family, plays a crucial role in a variety of cellular processes, including protein folding, protein-protein interactions, and the regulation of signal transduction pathways. Understanding the function and mechanisms of TTC4 is particularly important due to its involvement in important biological processes and potential implications in diseases. Studies have shown that mutations and dysregulation of TTC4 can be associated with various pathological conditions, including neurodegenerative diseases and cancers, making it a significant target for therapeutic research. The interest in TTC4 has led to numerous studies focused on its structure, function, and interactions with other cellular components. Researchers employ various techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to elucidate the three-dimensional structures of TTC4 and its complexes. These insights into its molecular architecture provide a foundation for understanding how TTC4 mediates its functions at a cellular level. Moreover, the development of TTC4 recombinant proteins allows for detailed biochemical assays and functional studies, paving the way for potential applications in drug discovery and the development of novel therapeutic strategies. Thus, the investigation of TTC4 and its role in cellular mechanisms remains a vital area of research with broad implications for understanding and treating human diseases.
