Analytical Data
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Gene name
FAM89B
- Application
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Alternative Names
FAM89B; Lrap25; Leucine repeat adapter protein 25
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5H3
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Expression Region
1-189aa
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AA Sequence
MNGLPSAEAP GGAGCALAGL PPLPRGLSGL LNASGGSWRE LERVYSQRSR IHDELSRAAR APDGPRHAAG AANAGPAAGP RRPVNLDSAL AALRKEMVGL RQLDMSLLCQ LWGLYESIQD YKHLCQDLSF CQDLSSSLHS DSSYPPDAGL SDDEEPPDAS LPPDPPPLTV PQTHNARDQW LQDAFHISL
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Molecular Weight
20.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FANCG, a crucial protein involved in the fanconi anemia (FA) pathway, plays a significant role in maintaining genomic stability by facilitating DNA repair mechanisms. Fanconi anemia is a rare genetic disorder characterized by hypersensitivity to DNA cross-linking agents, resulting in bone marrow failure, malignancies, and various developmental abnormalities. The FANCG gene, part of a complex network of FA genes, encodes a protein that is essential for the repair of DNA interstrand crosslinks, which can be induced by environmental agents or during normal cellular processes. Understanding the structure, function, and interactions of FANCG is vital for elucidating the pathological mechanisms underlying FA and for developing potential therapeutic strategies. Recent advancements in recombinant protein technology have enabled the production of purified FANCG for detailed biochemical and structural studies. This research aims to provide insights into the molecular functions of FANCG, its role in the FA pathway, and its potential as a target for innovative treatments that could mitigate the effects of DNA damage in FA patients and improve their life expectancy and quality of life. As the study of FANCG continues to progress, it holds promise for broadening our understanding of DNA repair mechanisms and their implications in cancer biology and other genetic disorders.
