Analytical Data
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基因名
TRIM6
- Application
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别名
TRIM6; RNF89; Tripartite motif-containing Protein 6; EC 2.3.2.27; RING finger Protein 89; RING-type E3 ubiquitin transferase TRIM6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9C030
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表达区间
1-488 aa
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氨基酸序列
MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ EGERSCPVCQ TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE DGKVICWLCE RSQEHRGHHT FLVEEVAQEY QEKFQESLKK LKNEEQEAEK LTAFIREKKT SWKNQMEPER CRIQTEFNQL RNILDRVEQR ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR CQGSTMELLQ DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF SSGKHYWEVD VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG YWVIGLQHNH EYRAYEDSSP SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP MTLRRPSS
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分子量
56.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIM6, a member of the Tripartite Motif (TRIM) family of proteins, plays a significant role in the immune response and antiviral defense mechanisms. The TRIM family is characterized by a RING finger domain, two B-box domains, and a coiled-coil region, which are crucial for mediating various cellular functions, including ubiquitination, protein-protein interactions, and modulation of signaling pathways. Research on TRIM6 has revealed its involvement in the regulation of immune responses against viral infections, particularly through the enhancement of interferon signaling and direct antiviral activities. Studies have shown that TRIM6 can facilitate the degradation of viral proteins and modulate the production of pro-inflammatory cytokines, highlighting its potential as a therapeutic target for viral diseases. Furthermore, the dysregulation of TRIM6 has been linked to different pathological conditions, including autoimmune diseases and cancer, underscoring its importance in maintaining cellular homeostasis. Given its multifaceted roles in immune regulation, the recombinant expression and characterization of TRIM6 can provide valuable insights into its functional mechanisms and therapeutic applications, paving the way for innovative strategies in combating viral infections and associated diseases.
