Analytical Data
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Gene name
TRIM49L2
- Application
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Alternative Names
TRIM49C; TRIM49L2; Tripartite motif-containing Protein 49C; Tripartite motif-containing Protein 49-like Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P0CI26
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Expression Region
1-452 aa
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AA Sequence
MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV QCSECTKSTE QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSQE HRYHRHRPIE WAAEEHREKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS WNWAFGVCNM YRKEKNQNEK IDGKEGLFLL GCIKNDIQCS LFTTSPLMLQ YIPKPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF
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Molecular Weight
52.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIM49L2 is a member of the Tripartite Motif (TRIM) protein family, which plays crucial roles in various biological processes, including immune response, cell proliferation, and stress response. The TRIM proteins are characterized by the presence of a RING finger domain, one or more B-box domains, and a coiled-coil region, allowing them to function as E3 ubiquitin ligases. While much attention has been given to other TRIM family members, TRIM49L2 remains relatively less studied. Recent research has suggested that it may be involved in the regulation of inflammatory responses and may play a role in the immune system's ability to combat viral infections. Additionally, alterations in TRIM49L2 expression have been associated with certain disease states, including autoimmune disorders and cancer, highlighting its potential as a biomarker or therapeutic target. Understanding the functional mechanisms of TRIM49L2 through recombinant protein studies could provide valuable insights into its role in cellular processes and its potential implications in health and disease. The production and characterization of TRIM49L2 recombinant proteins can facilitate the study of its interactions with other cellular proteins and elucidate its biological functions, paving the way for novel therapeutic strategies. This study aims to fill the knowledge gap surrounding TRIM49L2 by exploring its structure, function, and regulatory mechanisms, which could ultimately contribute to a better understanding of its role in human health and disease.
