Cat: PAX2000-12151

Recombinant Human TRIM34 Protein,His

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Analytical Data

  • Gene name

    TRIM34

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    TRIM34; IFP1; RNF21; Tripartite motif-containing Protein 34; Interferon-responsive finger Protein 1; RING finger Protein 21

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9BYJ4

  • Expression Region

    1-488 aa

  • AA Sequence

    MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM GGKSSCPVCG ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH GEKLLLFCKE DRKVICWLCE RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR LKKEEEEAEK LEADIREEKT SWKYQVQTER QRIQTEFDQL RSILNNEEQR ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR SQWSTMELLQ DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY WEVDVSKKTA WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI GLQNKCKYGV FEESLSSDPE VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP MTLCPPSS

  • Molecular Weight

    56.8 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

TRIM34, a member of the tripartite motif (TRIM) protein family, is gaining attention due to its potential roles in various cellular processes, including immune response, apoptosis, and cell proliferation. Research indicates that TRIM proteins are involved in the regulation of protein stability and the modulation of signaling pathways, making them crucial players in maintaining cellular homeostasis. TRIM34 has been implicated in the regulation of innate immunity and may play a role in the response to viral infections. Studies suggest that it may interact with other proteins to form complexes that influence the transcriptional activity of key immune-related genes. Given the increasing interest in the therapeutic potential of manipulating TRIM proteins for treating diseases such as cancer and autoimmune disorders, understanding the specific functions and mechanisms of TRIM34 is vital. Investigating the structural features of TRIM34, including its E3 ligase activity, could provide insights into its functional role in disease contexts and highlight possible avenues for drug development. The ongoing research aims to elucidate these aspects, with the hope of translating findings into practical applications in clinical settings.

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