Analytical Data
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基因名
PSMD4
- Application
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别名
PSMD4；MCB1；26S proteasome non-ATPase regulatory subunit 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55036
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表达区间
1-377aa
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氨基酸序列
MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN EKDLVKLAKR LKKEKVNVDI INFGEEEVNT EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA DALISSPILA GEGGAMLGLG ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA ASAAEAGIAT TGTEDSDDAL LKMTISQQEF GRTGLPDLSS MTEEEQIAYA MQMSLQGAEF GQAESADIDA SSAMDTSEPA KEEDDYDVMQ DPEFLQSVLE NLPGVDPNNE AIRNAMGSLA SQATKDGKKD KKEEDKK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD4, a member of the 19S regulatory complex of the proteasome, plays a critical role in protein degradation and cellular homeostasis. Its involvement in various cellular processes, such as cell cycle regulation, stress responses, and signal transduction, elevates its significance in maintaining proteostasis. Recent studies have indicated that dysregulation of PSMD4 is linked to several diseases, including cancer and neurodegenerative disorders, making it a potential biomarker and therapeutic target. Understanding the structure and function of PSMD4 through recombinant protein studies can provide insights into its mechanistic role in proteasomal activity and its interaction with other cellular components. By examining the biochemical properties and functional implications of PSMD4, researchers aim to reveal novel pathways that could lead to targeted treatments. Moreover, the use of PSMD4 recombinant protein allows for the exploration of its role in protein-protein interactions and post-translational modifications, thus enhancing our understanding of its contribution to cellular integrity and disease manifestation. This research not only has implications for basic biological understanding but also holds promise for the development of innovative therapeutic strategies for diseases associated with proteasomal dysfunction.
