Analytical Data
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Gene name
SPP2
- Application
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Alternative Names
SPP2；Sphingosine-1-phosphate phosphatase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13103
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Expression Region
30-211aa
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AA Sequence
F PVYDYDPSSL RDALSASVVK VNSQSLSPYL FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP ATCAFQRDYY VSTAVCRSTV KVSAQQVQGV HARCSWSSST SESYSSEEMI FGDMLGSHKW RNNYLFGLIS DESISEQFYD RSLGIMRRVL PPGNRRYPNH RHRARINTDF E
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPP2, a protein initially studied in the context of RNA processing and gene regulation, has garnered significant interest in molecular biology due to its potential implications in various cellular processes, including transcriptional regulation and stress response. As part of the serine/arginine-rich (SR) protein family, SPP2 plays a crucial role in the spliceosome machinery, influencing mRNA splicing and stability. Recent studies have shown that SPP2 is not only essential for proper splicing but also interacts with other proteins involved in transcriptional activation and chromatin remodeling. Research indicates that dysregulation of SPP2 may be linked to several diseases, including cancer and neurodegenerative disorders, making it a candidate for therapeutic targeting. The expression and function of SPP2 can be modulated in response to environmental stimuli, highlighting its role in cellular adaptation and signaling pathways. Consequently, recombinant SPP2 proteins are being utilized to dissect its functional mechanisms and interactions in vitro and in vivo. These studies are expanding our understanding of the molecular underpinnings of gene expression and the potential consequences of SPP2 dysregulation, thus providing insights into its roles in health and disease.
