Analytical Data
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Gene name
CLDN3
- Application
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Alternative Names
CLDN3；C7orf1；CPETR2；Claudin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15551
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Expression Region
1-220aa
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AA Sequence
MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
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Molecular Weight
26.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLDN3, or Claudin-3, is a member of the claudin family of proteins that play a critical role in forming tight junctions between epithelial cells, which are essential for maintaining cell polarity and regulating paracellular transport. Recent studies have highlighted the significance of CLDN3 in various pathological conditions, particularly in cancer, where its expression is often altered. Elevated levels of CLDN3 have been associated with the progression and metastasis of several tumors, indicating its potential as a biomarker for cancer diagnosis and prognosis. Additionally, CLDN3 has been implicated in the modulation of cellular signaling pathways and interactions with other tight junction proteins, influencing tissue homeostasis. As a result, research into the recombinant expression of CLDN3 protein has gained momentum, aimed at elucidating its structural and functional characteristics. The generation of a recombinant CLDN3 protein can facilitate the study of its role in tight junction integrity and its involvement in disease mechanisms. Furthermore, understanding the structural properties of CLDN3 can provide insights into how alterations in its expression affect cell behavior, potentially leading to targeted therapeutic strategies in cancer treatment and other disorders where tight junction dysfunction is implicated. The development and characterization of recombinant CLDN3 protein thus not only enhance our understanding of its biological functions but also open avenues for its application in clinical diagnostics and therapeutic interventions.
