Analytical Data
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Gene name
FAM125B
- Application
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Alternative Names
MVB12B; C9orf28; FAM125B; Multivesicular body subunit 12B; ESCRT-I complex subunit MVB12B; Protein FAM125B
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H7P6
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Expression Region
1-319aa
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AA Sequence
MRSCFCVRRS RDPPPPQPPP PPPQRGTDQS TMPEVKDLSE ALPETSMDPI TGVGVVASRN RAPTGYDVVA QTADGVDADL WKDGLFKSKV TRYLCFTRSF SKENSHLGNV LVDMKLIDIK DTLPVGFIPI QETVDTQEVA FRKKRLCIKF IPRDSTEAAI CDIRIMGRTK QAPPQYTFIG ELNSMGIWYR MGRVPRNHDS SQPTTPSQSS AASTPAPNLP RHISLTLPAT FRGRNSTRTD YEYQHSNLYA ISAMDGVPFM ISEKFSCVPE SMQPFDLLGI TIKSLAEIEK EYEYSFRTEQ SAAARLPPSP TRCQQIPQS
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Molecular Weight
50.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FAM125B, also known as family with sequence similarity 125 member B, is a protein that has garnered attention in biomedical research due to its potential roles in cellular processes and implications in various diseases. Originally identified through genomic studies, FAM125B is believed to be involved in cellular signaling pathways, including those related to cell proliferation, differentiation, and apoptosis. Its expression patterns have been linked to several types of cancer, where it may participate in tumorigenesis by regulating key oncogenic pathways. Additionally, FAM125B is thought to impact immune response and inflammatory processes, raising interest in its potential role in autoimmune diseases. The generation of recombinant FAM125B protein has become crucial for elucidating its biological functions, enabling researchers to conduct in vitro and in vivo studies. Understanding the structure and function of FAM125B through recombinant protein studies can provide insights into its mechanism of action and facilitate the development of therapeutic strategies targeting its pathways. The growing body of evidence suggests that FAM125B could serve as a biomarker for certain diseases or a novel target for drug development, highlighting the significance of its study in the fields of molecular biology and medicine.
