Analytical Data
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Gene name
TRAPPC1
- Application
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Alternative Names
TRAPPC1; BET5; MUM2; Trafficking Protein particle complex subunit 1; BET5 homolog; Multiple myeloma Protein 2; MUM-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5R8
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Expression Region
1-145 aa
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AA Sequence
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG
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Molecular Weight
16.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRAPPC1 (Transport protein particle complex 1) is a crucial component of the TRAPP (Transport protein particle) complexes, which play significant roles in vesicular transport processes within cells, particularly in the endoplasmic reticulum (ER) to Golgi apparatus interface. The TRAPPC1 protein has garnered attention due to its involvement in various cellular functions including Golgi organization, membrane trafficking, and cell signaling. Notably, mutations in the TRAPPC1 gene have been associated with a range of genetic disorders, particularly those affecting growth and development. Research has shown that TRAPPC1 is vital for the proper functioning of COPII vesicles that mediate protein export from the ER, thus underscoring its importance in maintaining cellular homeostasis. Furthermore, its role in maintaining cilia function and mediating pathogen entry has emerged as a critical area of study. The expression and purification of recombinant TRAPPC1 protein is essential for in-depth biochemical and structural studies, which can elucidate the molecular mechanisms governing its function. Studies involving TRAPPC1 not only enhance our understanding of intracellular trafficking but also provide insights into potential therapeutic targets for diseases associated with TRAPPC1 dysfunction. Therefore, the research on TRAPPC1 recombinant protein offers significant implications for cell biology and medicine, paving the way for innovative treatment strategies for related disorders.
