Analytical Data
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Gene name
TRAM2
- Application
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Alternative Names
TRAM2; KIAA0057; Translocating chain-associated membrane Protein 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15035
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Expression Region
1-370 aa
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AA Sequence
MAFRRRTKSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQKVRKEEIPRQLQYICLYLVHIAGAYLLNLSRLGLILLLLQYSTEFLFHTARLFYFADENNEKLFSAWAAVFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVCAAQAWLMWRFIHSQLRHWREYWNEQSAKRRVPATPRLPARLIKRESGYHENGVVKAENGTSPRTKKLKSP
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Molecular Weight
69.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRAM2, or Transport and Assembly Machinery 2, is a protein that plays a crucial role in the biogenesis of mitochondrial inner membrane proteins. It is involved in the translocation and assembly processes, ensuring that proteins are correctly integrated into the mitochondrial membrane, which is essential for maintaining mitochondrial function and overall cellular energy metabolism. Research into TRAM2 has gained significance as it may contribute to understanding various mitochondrial-related diseases, including neurodegenerative disorders, metabolic syndromes, and age-related conditions. Additionally, TRAM2's function in the mitochondrial protein import pathway highlights its potential as a therapeutic target. Recent studies have focused on elucidating the molecular mechanisms by which TRAM2 operates, investigating its interactions with other import components, and mapping its role in specific protein import pathways. Understanding the structure and function of TRAM2 not only sheds light on mitochondrial dynamics but also provides insight into broader biological processes, including cellular stress responses and apoptosis. With the rising interest in mitochondrial biology in health and disease, TRAM2 represents a significant area of research, aiming to reveal novel therapeutic avenues and enhance knowledge of mitochondrial physiology.
