Analytical Data
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基因名
TNPO3
- Application
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别名
Transportin-3. Importin-12. Imp12. Transportin-SR. TRN-SR
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5L0
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表达区间
1-605 aa
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氨基酸序列
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGIS
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分子量
94.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNPO3 (Transportin 3) is a member of the transportin family of nuclear transport receptors, primarily recognized for its role in the nuclear import of various proteins, including those containing a nuclear localization signal (NLS). Research into TNPO3 has gained traction due to its involvement in critical cellular processes and its potential implications in viral infections, particularly with the human immunodeficiency virus (HIV). HIV utilizes TNPO3 for the nuclear import of its integrase enzyme, an essential component for viral replication. Additionally, TNPO3 has been implicated in the regulation of various cellular pathways, including transcription, splicing, and the response to stress. Given its multifaceted roles, TNPO3 has emerged as a significant target for therapeutic intervention, particularly in the development of antiviral strategies. Studies have also suggested that dysregulation of TNPO3 may be linked to certain cancers and other diseases, making it a relevant focus for research in both virology and cancer biology. The recombinant expression of TNPO3 protein allows researchers to investigate its structure-function relationship and to explore its interactions with other cellular proteins and nucleic acids. Understanding the biochemical properties and transport mechanisms of TNPO3 may provide insights into cellular homeostasis and the molecular underpinnings of diseases associated with its dysfunction.
