Analytical Data
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Gene name
TNPO3
- Application
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Alternative Names
Transportin-3. Importin-12. Imp12. Transportin-SR. TRN-SR
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5L0
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Expression Region
1-605 aa
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AA Sequence
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGIS
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Molecular Weight
94.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TNPO3 (Transportin 3) is a member of the transportin family of nuclear transport receptors, primarily recognized for its role in the nuclear import of various proteins, including those containing a nuclear localization signal (NLS). Research into TNPO3 has gained traction due to its involvement in critical cellular processes and its potential implications in viral infections, particularly with the human immunodeficiency virus (HIV). HIV utilizes TNPO3 for the nuclear import of its integrase enzyme, an essential component for viral replication. Additionally, TNPO3 has been implicated in the regulation of various cellular pathways, including transcription, splicing, and the response to stress. Given its multifaceted roles, TNPO3 has emerged as a significant target for therapeutic intervention, particularly in the development of antiviral strategies. Studies have also suggested that dysregulation of TNPO3 may be linked to certain cancers and other diseases, making it a relevant focus for research in both virology and cancer biology. The recombinant expression of TNPO3 protein allows researchers to investigate its structure-function relationship and to explore its interactions with other cellular proteins and nucleic acids. Understanding the biochemical properties and transport mechanisms of TNPO3 may provide insights into cellular homeostasis and the molecular underpinnings of diseases associated with its dysfunction.
