Analytical Data
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基因名
F2RL1
- Application
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别名
F2RL1; GPR11; PAR2; Proteinase-activated receptor 2; PAR-2; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55085
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表达区间
1-397aa
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氨基酸序列
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
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分子量
44.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
F2RL1, also known as protease-activated receptor 2 (PAR2), is a member of the G protein-coupled receptor family and plays a crucial role in various physiological and pathological processes. This receptor is activated by serine proteases, which cleave its N-terminal domain, leading to cellular signaling cascades that influence inflammation, pain perception, and tissue repair. The abnormal regulation of F2RL1 has been implicated in several diseases, including chronic inflammatory disorders, cancer, and cardiovascular diseases. Given its significant involvement in these conditions, F2RL1 has emerged as a potential therapeutic target, prompting research into recombinant proteins for detailed characterization of its structure and function. The production of recombinant F2RL1 allows for the elucidation of its mechanistic pathways, receptor interactions, and potential ligands. Moreover, understanding F2RL1's role in signaling can enhance our knowledge of disease mechanisms and aid in the development of novel drug formulations. Through these studies, scientists aim to identify specific inhibitors or modulators of F2RL1, which could lead to innovative treatment strategies for diseases associated with its dysregulation. Overall, the exploration of F2RL1 and its recombinant proteins represents a promising frontier in biomedical research, with implications for developing more targeted and effective therapeutic interventions.
