Analytical Data
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Gene name
F2RL1
- Application
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Alternative Names
F2RL1; GPR11; PAR2; Proteinase-activated receptor 2; PAR-2; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55085
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Expression Region
1-397aa
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AA Sequence
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
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Molecular Weight
44.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
F2RL1, also known as protease-activated receptor 2 (PAR2), is a member of the G protein-coupled receptor family and plays a crucial role in various physiological and pathological processes. This receptor is activated by serine proteases, which cleave its N-terminal domain, leading to cellular signaling cascades that influence inflammation, pain perception, and tissue repair. The abnormal regulation of F2RL1 has been implicated in several diseases, including chronic inflammatory disorders, cancer, and cardiovascular diseases. Given its significant involvement in these conditions, F2RL1 has emerged as a potential therapeutic target, prompting research into recombinant proteins for detailed characterization of its structure and function. The production of recombinant F2RL1 allows for the elucidation of its mechanistic pathways, receptor interactions, and potential ligands. Moreover, understanding F2RL1's role in signaling can enhance our knowledge of disease mechanisms and aid in the development of novel drug formulations. Through these studies, scientists aim to identify specific inhibitors or modulators of F2RL1, which could lead to innovative treatment strategies for diseases associated with its dysregulation. Overall, the exploration of F2RL1 and its recombinant proteins represents a promising frontier in biomedical research, with implications for developing more targeted and effective therapeutic interventions.
