Analytical Data
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Gene name
F11R
- Application
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Alternative Names
CD 321; CD321; CD321 antigen; ESTM33; F11 receptor; F11R; JAM 1; JAM A; JAM; JAM-1; JAM-A; JAM1; JAM1_HUMAN; JAMA; JCAM; Jcam1; Junction adhesion molecule 1; Junction adhesion molecule; mouse; homolog of; Junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM 1; PAM-1; PAM1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y624
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Expression Region
1-299aa
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AA Sequence
MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV
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Molecular Weight
32.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
F11R, also known as Junctional Adhesion Molecule A (JAM-A), is a member of the immunoglobulin superfamily and plays a significant role in the regulation of cell adhesion and migration, particularly in immune response and inflammation. Its expression is prominent in endothelial and epithelial tissues, where it contributes to maintaining tight junctions and barrier integrity. Research has indicated that F11R is involved in various physiological and pathological processes, including leukocyte transmigration, angiogenesis, and tumor progression, thus highlighting its potential as a therapeutic target. In particular, studies have shown that dysregulation of F11R is associated with several diseases, such as cancer, autoimmune disorders, and infectious diseases. Therefore, generating recombinant F11R protein is crucial for elucidating its functional properties and interactions at the molecular level, as well as for the development of potential interventions targeting F11R-mediated pathways. The recombinant protein can be utilized in various applications, including structural studies, drug discovery, and the development of vaccines or therapeutic antibodies. Understanding the biophysical characteristics and biological functions of recombinant F11R will advance our knowledge of its role in health and disease, ultimately contributing to the design of novel therapeutic strategies aimed at modulating F11R activity for clinical benefit.
