Analytical Data
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基因名
DRD4
- Application
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别名
DRD4；D(4) dopamine receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21917
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表达区间
1-419aa
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氨基酸序列
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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分子量
43.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dopamine receptor D4 (DRD4) is a G-protein coupled receptor that plays a pivotal role in the dopaminergic signaling pathway, influencing various neurological processes including mood regulation, attention, and learning. Variations in the gene encoding DRD4 have been associated with a range of behavioral and psychological conditions, such as attention deficit hyperactivity disorder (ADHD), schizophrenia, and substance abuse. Understanding the structural and functional dynamics of DRD4 is crucial for developing targeted therapeutic strategies. Recombinant protein technology has enabled researchers to produce human DRD4 in vitro, facilitating studies on its pharmacological properties, interaction with ligands, and the effects of genetic polymorphisms. Investigating DRD4 as a recombinant protein can provide insights into its conformation, signaling mechanisms, and the molecular basis for its role in neuropsychiatric disorders. Moreover, by employing techniques like X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, scientists are able to elucidate the three-dimensional structure of DRD4, thus contributing to the design of novel drugs that modulate its activity. As the prevalence of dopamine-related disorders continues to rise, the study of DRD4 recombinant protein is becoming increasingly relevant, offering potential pathways for innovative treatments and a deeper understanding of complex behavioral phenomena.
