Analytical Data
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Gene name
DRD4
- Application
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Alternative Names
DRD4；D(4) dopamine receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21917
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Expression Region
1-419aa
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AA Sequence
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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Molecular Weight
43.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Dopamine receptor D4 (DRD4) is a G-protein coupled receptor that plays a pivotal role in the dopaminergic signaling pathway, influencing various neurological processes including mood regulation, attention, and learning. Variations in the gene encoding DRD4 have been associated with a range of behavioral and psychological conditions, such as attention deficit hyperactivity disorder (ADHD), schizophrenia, and substance abuse. Understanding the structural and functional dynamics of DRD4 is crucial for developing targeted therapeutic strategies. Recombinant protein technology has enabled researchers to produce human DRD4 in vitro, facilitating studies on its pharmacological properties, interaction with ligands, and the effects of genetic polymorphisms. Investigating DRD4 as a recombinant protein can provide insights into its conformation, signaling mechanisms, and the molecular basis for its role in neuropsychiatric disorders. Moreover, by employing techniques like X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, scientists are able to elucidate the three-dimensional structure of DRD4, thus contributing to the design of novel drugs that modulate its activity. As the prevalence of dopamine-related disorders continues to rise, the study of DRD4 recombinant protein is becoming increasingly relevant, offering potential pathways for innovative treatments and a deeper understanding of complex behavioral phenomena.
