Analytical Data
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基因名
TNKS
- Application
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别名
ADP-ribosyltransferase diphtheria toxin-like 5;ARTD5;Poly [ADP-ribose] polymerase 5A;Protein poly-ADP-ribosyltransferase tankyrase-1;EC 2.4.2.-;TNKS-1;TRF1-interacting ankyrin-related ADP-ribose polymerase;Tankyrase I;Tankyrase-1;TANK1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95271
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表达区间
181-964 aa
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氨基酸序列
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC
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分子量
91.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNKS (Tankyrase) proteins are a family of poly(ADP-ribosyl) polymerases that play a crucial role in various cellular processes, including telomere maintenance, Wnt signaling, and regulating the stability of certain proteins through post-translational modifications. Historically, their dysregulation has been implicated in several diseases, including cancer, making them a significant target for therapeutic interventions. Researchers have increasingly focused on understanding the molecular mechanisms by which TNKS proteins influence cell proliferation and survival, particularly in tumor cells. The structural features of TNKS proteins, such as their unique ankyrin repeat domains, enable specific interactions with various substrates, providing a rich avenue for designing selective inhibitors. Additionally, the potential of TNKS inhibitors has garnered attention due to their ability to disrupt oncogenic signaling pathways and enhance the effectiveness of existing cancer therapies. As a result, the study of TNKS reconstituted proteins has become a vital area of research, with the aim of unveiling their biological functions and therapeutic potentials, ultimately contributing to the development of novel cancer treatment strategies.
