Analytical Data
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Gene name
ZNF265
- Application
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Alternative Names
ZRANB2; ZIS; ZNF265; Zinc finger Ran-binding domain-containing Protein 2; Zinc finger Protein 265; Zinc finger; splicing
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95218
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Expression Region
1-320 aa
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AA Sequence
MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPESQVIGENTKQP
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Molecular Weight
52.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF265 (Zinc Finger Protein 265) is a member of the zinc finger protein family, which is characterized by the presence of zinc finger motifs that mediate protein-DNA interactions. Research into ZNF265 has gained traction due to its potential role in gene regulation, particularly in the context of cancer biology and developmental processes. Initial studies suggested that ZNF265 may act as a transcriptional repressor, influencing various cellular pathways linked to cell proliferation and differentiation. Furthermore, aberrant expression of ZNF265 has been implicated in certain malignancies, marking it as a potential biomarker or therapeutic target. The recombinant protein version of ZNF265 is crucial for elucidating its functional mechanisms, as it allows researchers to study its DNA binding properties, interaction with other proteins, and influence on gene expression in a controlled environment. By producing this protein in a heterologous system, such as E. coli or insect cells, scientists can obtain large quantities of ZNF265 for biochemical assays, structural studies, and in vivo analyses. Understanding ZNF265's multifaceted roles in cellular processes may provide valuable insights into the molecular underpinnings of diseases and open avenues for novel therapeutic strategies. Overall, the study of ZNF265 recombinant protein represents a critical step towards deciphering the complexities of gene regulation and its implications in health and disease.
