Analytical Data
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Gene name
ZNF263
- Application
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Alternative Names
ZNF263; FPM315; ZKSCAN12; Zinc finger Protein 263; Zinc finger Protein FPM315; Zinc finger Protein with KRAB and SCAN domains 12
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14978
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Expression Region
1-683 aa
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AA Sequence
MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ EAAGPREALS RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR VQELHPESGE EAVTLVEDMQ RELGRLRQQV TNHGRGTEVL LEEPLPLETA RESPSFKLEP METERSPGPR LQELLGPSPQ RDPQAVKERA LSAPWLSLFP PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA LSRDTVQESY ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE GGMEQALAGA SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH AAERLCMGVD CTEIFGGNPR FLSLHRAHLG EEAHKCLECG KCFSQNTHLT RHQRTHTGEK PYQCNICGKC FSCNSNLHRH QRTHTGEKPY KCPECGEIFA HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH ERERLYPFSE CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL RTHTGERPYK CSECGESFSR SSRLMSHQRT HTG
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Molecular Weight
77.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF263, a member of the zinc finger protein family, has garnered significant interest in the field of molecular biology due to its potential role in gene regulation and its implications in various biological processes. This protein is characterized by its unique zinc finger motifs, which facilitate DNA binding and protein-protein interactions, highlighting its importance in transcriptional regulation. Recent studies suggest that ZNF263 may act as a transcriptional repressor, influencing cell differentiation, proliferation, and apoptosis. Additionally, its involvement in chromatin remodeling and epigenetic regulation positions ZNF263 as a critical player in maintaining cellular homeostasis and may have implications in cancer biology and other diseases. Given its functional diversity and regulatory capabilities, the recombinant production of ZNF263 protein is crucial for understanding its biochemical properties and interactions. Research efforts have focused on developing expression systems to generate sufficient amounts of this protein, allowing for in-depth biochemical assays and structural studies. By elucidating the molecular mechanisms underlying ZNF263's function, researchers aim to uncover its potential as a therapeutic target in diseases associated with dysregulated gene expression.
