Analytical Data
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Gene name
EXOSC6
- Application
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Alternative Names
EXOSC6; MTR3; Exosome complex component MTR3; Exosome component 6; mRNA transport regulator 3 homolog; hMtr3; p11
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5RKV6
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Expression Region
1-272aa
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AA Sequence
MPGDHRRIRG PEESQPPQLY AADEEEAPGT RDPTRLRPVY ARAGLLSQAK GSAYLEAGGT KVLCAVSGPR QAEGGERGGG PAGAGGEAPA ALRGRLLCDF RRAPFAGRRR RAPPGGCEER ELALALQEAL EPAVRLGRYP RAQLEVSALL LEDGGSALAA ALTAAALALA DAGVEMYDLV VGCGLSLAPG PAPTWLLDPT RLEEERAAAG LTVALMPVLN QVAGLLGSGE GGLTESWAEA VRLGLEGCQR LYPVLQQSLV RAARRRGAAA QP
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Molecular Weight
28.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EXOSC6, also known as exosome component 6, is a crucial component of the exosome complex, a multi-subunit ribonucleoprotein complex responsible for the degradation of RNA in eukaryotic cells. Research into EXOSC6 has gained importance due to its association with various cellular processes, including RNA processing, surveillance, and regulation. Mutations in the EXOSC6 gene have been linked to rare genetic disorders, such as pontocerebellar hypoplasia, which is characterized by neurodevelopmental issues and motor function impairment. These findings emphasize the significance of EXOSC6 in maintaining RNA homeostasis and its potential role in neurological diseases. Furthermore, understanding the structure and function of EXOSC6 can provide insights into how RNA decay pathways are regulated and their implications in disease mechanisms. The development of recombinant EXOSC6 protein for study purposes allows researchers to investigate its biochemical properties, interactions with other exosomal components, and its role in RNA metabolism. Consequently, ongoing studies focus on elucidating the functional dynamics of EXOSC6 within the exosome complex, paving the way for novel therapeutic strategies targeting RNA-related pathologies.
