Cat: PAX2000-12073

Recombinant Human TMTC4 Protein,GST

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Analytical Data

  • Gene name

    TMTC4

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    TMTC4; Protein O-mannosyl-transferase TMTC4; EC 2.4.1.109; Transmembrane and TPR repeat-containing Protein 4

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q5T4D3

  • Expression Region

    1-395 aa

  • AA Sequence

    MLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLVSAGCPVPVEGKMGYFSYL

  • Molecular Weight

    70.9 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

TMTC4 (Transmembrane and Tetratricopeptide Repeats Containing 4) is a protein implicated in various cellular processes, and its research has gained traction due to its potential associations with neurological disorders and other diseases. As a member of the TMTC family, TMTC4 is believed to play a crucial role in the maintenance of cellular calcium homeostasis and the regulation of cellular signaling pathways. Recent studies suggest that alterations in TMTC4 expression or function may contribute to neurodegenerative conditions, highlighting its importance in neuronal health. Furthermore, the protein's tetratricopeptide repeats suggest a role in protein-protein interactions, which is essential for various biological functions, including apoptosis and oxidative stress responses. Understanding the molecular mechanisms by which TMTC4 exerts its effects can provide insights into its potential as a therapeutic target for the treatment of conditions related to calcium dysregulation and neuronal impairment. Overall, research on TMTC4 not only aims to elucidate its biological functions but also hopes to unravel its contributions to disease pathology, thereby paving the way for new clinical interventions and therapeutic strategies.

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