Analytical Data
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Gene name
ETV6
- Application
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Alternative Names
ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41212
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Expression Region
1-452aa
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AA Sequence
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
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Molecular Weight
75.46 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ETV6, also known as Telomeric Repeat-Containing RNA (TERC), is a gene that encodes a transcription factor playing a crucial role in hematopoiesis and early development. Research has shown that ETV6 is frequently involved in chromosomal rearrangements, particularly in various hematological malignancies, such as acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML). The most notable of these rearrangements is the ETV6-RUNX1 fusion, which results from a translocation between chromosomes 12 and 21, and is a key genetic alteration associated with pediatric ALL. These fusions alter normal gene expression pathways, contributing to the pathogenesis of leukemia by promoting uncontrolled cell proliferation and inhibiting apoptosis. Recent studies have also suggested that ETV6 may function as a tumor suppressor, with mutations or deletions leading to aberrant signaling and increased cancer susceptibility. Understanding the molecular mechanisms underlying ETV6-related fusions and their role in leukemogenesis is essential for developing targeted therapies and improving treatment outcomes for affected patients. Further research into ETV6's interaction with other oncogenic pathways may also provide insights into the broader implications of its dysregulation in various cancers, highlighting the need for continued investigation in the field of cancer biology.
