Analytical Data
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Gene name
ESX1L
- Application
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Alternative Names
ESX1; ESX1L; ESX1R; Homeobox protein ESX1; Extraembryonic; spermatogenesis; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N693
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Expression Region
1-406aa
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AA Sequence
MESLRGYTHS DIGYRSLAVG EDIEEVNDEK LTVTSLMARG GEDEENTRSK PEYGTEAENN VGTEGSVPSD DQDREGGGGH EPEQQQEEPP LTKPEQQQEE PPLLELKQEQ EEPPQTTVEG PQPAEGPQTA EGPQPPERKR RRRTAFTQFQ LQELENFFDE SQYPDVVARE RLAARLNLTE DRVQVWFQNR RAKWKRNQRV LMLRNTATAD LAHPLDMFLG GAYYAAPALD PALCVHLVPQ LPRPPVLPVP PMPPRPPMVP MPPRPPIAPM PPMAPVPPGS RMAPVPPGPR MAPVPPWPPM APVPPWPPMA PVPTGPPMAP VPPGPPMARV PPGPPMARVP PGPPMAPLPP GPPMAPLPPG PPMAPLPPGP PMAPLPPRSH VPHTGLAPVH ITWAPVINSY YACPFF
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Molecular Weight
44.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The ESX1L protein, part of the ESX-1 secretion system, is a key component in the pathogenicity of certain mycobacteria, particularly Mycobacterium tuberculosis. This system is essential for the secretion of virulence factors that enable the bacteria to manipulate host cell responses, facilitating infection and survival within macrophages. Research into ESX1L has gained momentum due to its potential role in immune evasion and its involvement in promoting inflammation and granuloma formation, which are characteristic responses to mycobacterial infections. Understanding the structure and function of ESX1L can provide valuable insights into the molecular mechanisms underpinning mycobacterial pathogenesis. Moreover, it offers promising avenues for the development of novel therapeutic strategies and vaccine candidates aimed at enhancing host immune responses or inhibiting the secretion system. The exploration of ESX1L not only contributes to our understanding of bacterial physiology and host-pathogen interactions but also highlights the intricate balance between microbial survival strategies and host immune defenses. This area of research is particularly relevant given the global burden of tuberculosis and the necessity for effective treatment options in the face of rising drug resistance.
