Analytical Data
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Gene name
DNM2
- Application
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Alternative Names
DNM2；DNMT2；tRNA (cytosine(38)-C(5))-methyltransferase
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Species
Human
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Source
E. coli
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Tag
His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P50570
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Expression Region
1-870aa
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AA Sequence
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLEN FVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQE IEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPP DIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRT IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRA ALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKL QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQ VDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRT GLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQ QRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESL SWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDL RQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLE RQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLY SSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPP PVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGA AASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRR PPAAPSRPTIIRPAEPSLLD
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Molecular Weight
98 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Dynamin-2 (DNM2) is a large GTPase belonging to the dynamin family, which plays a critical role in membrane dynamics, particularly in the processes of endocytosis and vesicle trafficking. Mutations in the DNM2 gene have been implicated in various human diseases, including centronuclear myopathy and neuropathies, highlighting its importance in cellular function. Given its essential role in cellular processes, researchers have focused on characterizing DNM2's structure and function. Recombinant DNM2 protein studies have enabled the exploration of its GTPase activity, membrane binding properties, and oligomerization behavior. These studies are integral for understanding the molecular mechanisms underlying DNM2's functions, as well as its involvement in disease. Additionally, the development of DNM2 inhibitors or modulators is a promising therapeutic avenue, potentially offering new treatments for conditions associated with DNM2 dysregulation. By elucidating the functional dynamics of DNM2 through recombinant protein research, scientists aim to gain deeper insights into its role in health and disease, paving the way for innovative approaches to therapeutic intervention.
