Analytical Data
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Gene name
TMCO4
- Application
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Alternative Names
TMCO4; Transmembrane and coiled-coil domain-containing Protein 4
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5TGY1
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Expression Region
1-634 aa
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AA Sequence
MAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTAFASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDGHYDARARVLVCHMTSLLQVPLEELDVLEEMFLESLKEIKEEESEMAEASRKKKENRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRVGAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSREQYCLAWEAKYLMELGNALETILSGLANMVAQEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLHVAGLQPVLLQDRRVENVDLTSVVSGHLDYAKQMDAILKAVGIRTKPGWDEKGLLLAPGCLPSEEPRQAAAAASSGETPHQVGQTQGPISGDTSKLAMSTDPSQAQVPVGLDQSEGASLPAAASPERPPICSHGMDPNPLGCPDCACKTQGPSTGLD
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Molecular Weight
94.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMCO4 is a membrane protein that has garnered significant interest in the field of cell biology due to its potential roles in cellular processes such as calcium homeostasis and endoplasmic reticulum (ER) stress response. As a part of the TMCO family, TMCO4 is believed to participate in the regulation of ion transport and influencing the dynamics of the cellular environment, particularly under stress conditions. Research has indicated that TMCO4 may have implications in various physiological and pathological contexts, including its involvement in neurodegenerative diseases and cancer, making it a potential target for therapeutic interventions. Despite its importance, the molecular mechanisms underlying TMCO4's functions remain largely uncharacterized, prompting further investigation through the development of recombinant TMCO4 proteins. This recombinant approach will facilitate in-depth studies of TMCO4's structure, function, and interactions within the cell, enabling researchers to elucidate its role in cellular signaling and stress responses. By generating TMCO4 in a controlled laboratory setting, scientists can explore its biophysical properties and conduct functional assays to discover how alterations in TMCO4 expression or activity may contribute to disease states. Thus, the study of recombinant TMCO4 not only aims to enhance our understanding of its biological roles but also paves the way for potential clinical applications in targeting TMCO4-related pathologies.
