Analytical Data
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基因名
TMCO4
- Application
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别名
TMCO4; Transmembrane and coiled-coil domain-containing Protein 4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5TGY1
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表达区间
1-634 aa
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氨基酸序列
MAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTAFASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDGHYDARARVLVCHMTSLLQVPLEELDVLEEMFLESLKEIKEEESEMAEASRKKKENRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRVGAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSREQYCLAWEAKYLMELGNALETILSGLANMVAQEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLHVAGLQPVLLQDRRVENVDLTSVVSGHLDYAKQMDAILKAVGIRTKPGWDEKGLLLAPGCLPSEEPRQAAAAASSGETPHQVGQTQGPISGDTSKLAMSTDPSQAQVPVGLDQSEGASLPAAASPERPPICSHGMDPNPLGCPDCACKTQGPSTGLD
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分子量
94.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMCO4 is a membrane protein that has garnered significant interest in the field of cell biology due to its potential roles in cellular processes such as calcium homeostasis and endoplasmic reticulum (ER) stress response. As a part of the TMCO family, TMCO4 is believed to participate in the regulation of ion transport and influencing the dynamics of the cellular environment, particularly under stress conditions. Research has indicated that TMCO4 may have implications in various physiological and pathological contexts, including its involvement in neurodegenerative diseases and cancer, making it a potential target for therapeutic interventions. Despite its importance, the molecular mechanisms underlying TMCO4's functions remain largely uncharacterized, prompting further investigation through the development of recombinant TMCO4 proteins. This recombinant approach will facilitate in-depth studies of TMCO4's structure, function, and interactions within the cell, enabling researchers to elucidate its role in cellular signaling and stress responses. By generating TMCO4 in a controlled laboratory setting, scientists can explore its biophysical properties and conduct functional assays to discover how alterations in TMCO4 expression or activity may contribute to disease states. Thus, the study of recombinant TMCO4 not only aims to enhance our understanding of its biological roles but also paves the way for potential clinical applications in targeting TMCO4-related pathologies.
