Analytical Data
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Gene name
TIMELESS
- Application
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Alternative Names
FLJ20516; TIMELESS interacting Protein; TIMELESS-interacting Protein; TIPIN; TIPIN_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVW5
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Expression Region
1-301 aa
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AA Sequence
MLEPQENGVI DLPDYEHVED ETFPPFPPPA SPERQDGEGT EPDEESGNGA PVRVPPKRTV KRNIPKLDAQ RLISERGLPA LRHVFDKAKF KGKGHEAEDL KMLIRHMEHW AHRLFPKLQF EDFIDRVEYL GSKKEVQTCL KRIRLDLPIL HEDFVSNNDE VAENNEHDVT STELDPFLTN LSESEMFASE LSRSLTEEQQ QRIERNKQLA LERRQAKLLS NSQTLGNDML MNTPRAHTVE EVNTDEDQKE ESNGLNEDIL DNPCNDAIAN TLNEEETLLD QSFKNVQQQL DATSRNITEA R
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Molecular Weight
34.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of TIMLESS, a critical protein involved in DNA damage response and repair, has gained significant attention in recent years. TIMLESS, originally identified in yeast, plays a vital role in maintaining genomic stability by regulating the repair processes of various forms of DNA damage. Research has highlighted its involvement in the cellular response to oxidative stress and its essential function in the replication fork stability during DNA replication. Mutations or dysregulation of TIMLESS have been implicated in various human diseases, including cancer, where compromised DNA repair mechanisms can lead to genomic instability and tumorigenesis. As our understanding of TIMLESS deepens, it opens up new avenues for therapeutic interventions, particularly in enhancing the efficacy of DNA-damaging agents used in cancer treatment. Moreover, the potential for TIMLESS as a biomarker for cancer prognosis and treatment response is also being explored. Overall, the ongoing research into TIMLESS underscores its significance in cellular health and disease, highlighting the need for further investigation into its molecular mechanisms and interactions within the complex network of cellular responses to DNA damage.
