Analytical Data
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基因名
THEMIS
- Application
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别名
C6orf190; C6orf207; MGC163388; Protein THEMIS; SIGNALING PHOSPHOProtein SPECIFIC FOR T CELLS; SPOT; THEMIS; THMS1_HUMAN; Thymocyte expressed molecule involved in selection; Thymocyte selection associated; Thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N1K5
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表达区间
1-641 aa
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氨基酸序列
MALSLEEFVH SLDLRTLPRV LEIQAGIYLE GSIYEMFGNE CCFSTGEVIK ITGLKVKKII AEICEQIEGC ESLQPFELPM NFPGLFKIVA DKTPYLTMEE ITRTIHIGPS RLGHPCFYHQ KDIKLENLII KQGEQIMLNS VEEIDGEIMV SCAVARNHQT HSFNLPLSQE GEFYECEDER IYTLKEIVEW KIPKNRTRTV NLTDFSNKWD STNPFPKDFY GTLILKPVYE IQGVMKFRKD IIRILPSLDV EVKDITDSYD ANWFLQLLST EDLFEMTSKE FPIVTEVIEA PEGNHLPQSI LQPGKTIVIH KKYQASRILA SEIRSNFPKR HFLIPTSYKG KFKRRPREFP TAYDLEIAKS EKEPLHVVAT KAFHSPHDKL SSVSVGDQFL VHQSETTEVL CEGIKKVVNV LACEKILKKS YEAALLPLYM EGGFVEVIHD KKQYPISELC KQFRLPFNVK VSVRDLSIEE DVLAATPGLQ LEEDITDSYL LISDFANPTE CWEIPVGRLN MTVQLVSNFS RDAEPFLVRT LVEEITEEQY YMMRRYESSA SHPPPRPPKH PSVEETKLTL LTLAEERTVD LPKSPKRHHV DITKKLHPNQ AGLDSKVLIG SQNDLVDEEK ERSNRGATAI AETFKNEKHQ K
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分子量
73.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
THEMIS (Thymocyte-expressed molecule involved in selection) is a critical protein involved in T-cell development and immune system regulation. Found predominantly in thymocytes, THEMIS plays a significant role in the positive and negative selection of T-cells, processes essential for generating a functional and self-tolerant T-cell repertoire. Research has shown that THEMIS interacts with various signaling pathways, notably those involving the T-cell receptor (TCR), and influences downstream signals that determine thymocyte fate. Mutations or alterations in THEMIS expression can lead to severe immunological disorders, such as autoimmune diseases and immunodeficiencies. Given its pivotal role in T-cell maturation and function, the study of THEMIS has garnered attention in both basic immunology and therapeutic applications, including vaccine development and cancer immunotherapy. Researchers continue to explore its structural properties, functional mechanisms, and potential as a biomarker or therapeutic target. Understanding THEMIS's role could provide valuable insights into T-cell biology and broader implications for immune system health and disease management.
