Analytical Data
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基因名
ELA2
- Application
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别名
Bone marrow serine protease; ELA2; ELANE; Elastase 2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE; Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Medullasin; NE; Neutrophil elastase; PMN E; PMN elastase; Polymorphonuclear elastase; SCN1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08246
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表达区间
30-267aa
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氨基酸序列
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
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分子量
52.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELA2, or Endothelial Leukocyte Adhesion Molecule 2, is a key player in the immune system and plays a significant role in mediating the adhesion of leukocytes to the endothelium during inflammatory responses. The study of ELA2 recombinant proteins has garnered attention due to their potential therapeutic applications in various inflammatory and autoimmune diseases. Researchers have focused on understanding the molecular mechanisms of ELA2 function, including its interactions with integrins and other adhesion molecules, which are critical in the recruitment of immune cells to sites of inflammation. Moreover, the production of ELA2 as a recombinant protein in systems such as bacteria or mammalian cells enables detailed structural and functional analyses. These studies not only contribute to our comprehension of ELA2's role in vascular biology but also pave the way for the development of targeted therapies that could modulate its activity in pathological conditions. Additionally, understanding the signaling pathways and regulatory mechanisms that govern ELA2 expression may lead to innovative strategies for managing chronic inflammatory diseases, thus highlighting the importance of ongoing research into this recombinant protein.
