Analytical Data
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Gene name
TNKS2
- Application
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Alternative Names
TNKS2；PARP5B；TANK2；TNKL；Poly [ADP-ribose] polymerase tankyrase-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2K2
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Expression Region
667-1166aa
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AA Sequence
PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL HNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA HGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVR SPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSL EKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIG INAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQ SVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEV SEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSS KSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMA HSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG
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Molecular Weight
81 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The TNKS2 (Tankyrase 2) protein is a member of the tankyrase family, which plays a crucial role in various cellular processes, including telomere maintenance, cell proliferation, and DNA damage response. Initially identified for its poly(ADP-ribose) polymerase activity, TNKS2 interacts with multiple substrates involved in signal transduction and cellular regulation, making it a vital player in the Wnt signaling pathway. Dysregulation of TNKS2 has been implicated in various cancers, particularly as it influences the degradation of Axin and promotes β-catenin stabilization, a key factor in tumorigenesis. Given its significant function in cancer progression, TNKS2 has emerged as a promising therapeutic target, prompting researchers to explore its structure and enzymatic activities. Understanding the molecular mechanisms and interactions of TNKS2 could pave the way for the development of novel inhibitors that may effectively hinder cancer cell proliferation and survival, ultimately contributing to more effective cancer treatment strategies. Current studies are focusing on the biochemical characterization and the potential application of TNKS2 inhibitors in clinical settings, hoping to exploit its role in cancer signaling pathways for therapeutic benefit.
