Analytical Data
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基因名
EIF3S7
- Application
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别名
eIF 3 zeta; eIF-3-zeta; eIF3 p66; eIF3 zeta; eIF3d; EIF3D_HUMAN; eIF3p66; EIF3S7; Eukaryotic translation initiation factor 3 subunit 7; Eukaryotic translation initiation factor 3 subunit 7 zeta 66/67kDa; Eukaryotic translation initiation factor 3 subunit D; MGC126526
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15371
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表达区间
1-548aa
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氨基酸序列
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET
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分子量
85.91 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EIF3S7 (Eukaryotic Translation Initiation Factor 3 Subunit 7) is a critical component of the eukaryotic translation initiation factor 3 (eIF3) complex, which plays a pivotal role in the regulation of protein synthesis. This protein is involved in the initiation phase of translation by facilitating the binding of mRNA to the ribosomal machinery. Research on EIF3S7 has gained significant attention, as its expression and function are implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of EIF3S7 has been associated with several diseases, especially cancer, where altered protein synthesis can contribute to tumorigenesis and metastasis. The study of recombinant EIF3S7 protein allows for the exploration of its structural and functional properties, as well as its interactions with other components of the eIF3 complex and mRNA. Understanding the intricate mechanisms underlying EIF3S7's role in translation initiation can provide insights into potential therapeutic strategies that target protein synthesis in cancer therapy and other diseases linked to translation dysregulation. Additionally, recombinant EIF3S7 can serve as a valuable tool for high-throughput screening assays aimed at identifying small-molecule inhibitors that selectively target aberrant translation initiation pathways. Through the investigation of EIF3S7, researchers hope to elucidate the fundamental processes of translation initiation and their implications in health and disease.
