Analytical Data
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基因名
BCR
- Application
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别名
BCR；BCR1；D22S11；Breakpoint cluster region Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11274
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表达区间
1-695aa
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氨基酸序列
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPR
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分子量
120 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCR (breakpoint cluster region) protein, a key player in cell signaling, has garnered significant attention in cancer research, particularly due to its association with chronic myeloid leukemia (CML). The BCR-ABL fusion protein, resulting from a chromosomal translocation involving the BCR gene on chromosome 22 and the ABL gene on chromosome 9, leads to uncontrolled cellular proliferation and is a hallmark of CML. This fusion protein exhibits constitutive tyrosine kinase activity, driving oncogenic signaling pathways. As researchers delve into the molecular mechanisms underlying BCR-ABL-mediated cancer progression, the study of BCR recombinant proteins has become essential for understanding their structure-function relationships. Recombinant BCR proteins can be used to investigate the biochemical properties and interaction networks of the BCR-ABL fusion, facilitating the development of targeted therapies. Additionally, the expression of BCR-derived proteins in various model systems allows for the elucidation of signaling cascades activated by BCR-ABL and the identification of potential drug targets. The advancement of BCR recombinant protein research not only contributes to a deeper understanding of leukemia pathogenesis but also paves the way for innovative treatment strategies, including tyrosine kinase inhibitors and immunotherapeutic approaches. As scientists continue to explore the complexities of BCR protein functions, this research holds promise for improving clinical outcomes for patients affected by BCR-ABL-related malignancies.
